It took brazen clinicians, however, to pursue oxygen as a therapeutic resource for patients with chronic lung disease because of the concern in the 20th century of the risks of oxygen toxicity. In the modern era, physiologists pursued the chemical nature of oxygen and its physiologic interaction with cellular metabolism and gas transport. The application of oxygen to chronic lung disease, however, took several centuries. ![]() Within a relatively short period, early investigators not only discovered oxygen but also recognized its importance to life and its role in respiration. ![]() The history of oxygen from discovery to clinical application for patients with chronic lung disease represents a long and storied journey.
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